The two-compartment vancomycin adult model implemented in DoseMeRx is derived from a retrospective study with a cohort of 1,812 patients. This model is particularly useful for AUC-based dosing as it models both the distribution and elimination phases of vancomycin.
Vancomycin dosing in critically-ill / ICU patients using our complex model
As this model fits a more complex pharmacokinetic curve, in order to get the best individual fit, two random lab results (not necessarily on the same dose) are most effective at individualizing the two phases for the patient using this model. The use of this model is highly recommended in complex patients already having multiple levels taken, such as those in ICU.
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